White Willow Bark Extract contains salicin, which the body converts to salicylic acid and has the same effect on the body as aspirin without any of the side effects. In fact, White Willow Bark Extract was the basis for the synthesis of aspirin. History of usage of White Willow Bark goes back as far as 500 BC when ancient Chinese healers began using it to control pain. Native Americans also discovered the value of the Willow tree for relieving pain from headaches and rheumatism and reducing fevers.

As a "natural aspirin", salicin is used to treat mild fever, colds, infections (influenza), acute and chronic rheumatic discomfort, headache and pain caused by inflammation. As a natural configuration, salicylic acid can be converted into salicylic acid in the blood and liver through the gastrointestinal system. The conversion process takes hours, so the results are not immediately felt by the body, but the general effect lasts for hours.